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Schooling sessions consisted of three to 6 cycles. Drug instruction entailed infusion of ?9-THC (0.one mg/kg i.v.) or rimonabant (one mg/kg i.v.) in the very first moment of the 1st of a few cycles; sham (uninteresting stress placed on the pores and skin overlying the vascular obtain port) was administered in the 1st minute of the subsequent cycles
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Probable metabolites of the cannabimimetic agent JWH-018 were synthesised, characterised to probe for his or her in vivo technology and urinary excretion, and an LC-MS/MS-based analytical assay was validated to allow the detection of Jwh-018 administration in drug testing programmes.Activation of CB1 receptors by exogenous cannabinoids and by endog
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